RevBrasAnestesiol.2019;69(5):432---438
Capsaicin topical cream (8%) for the treatment of my ofascial pain syndrome
Universidade Estadual Paulista (Unesp), Faculdade de Engenharia, Departamento de Engenharia
Industrial, Bauru, SP, Brazil Received 3April 2019;

My ofascial pain syndrome is a common causeofmusculoskeletal pain.

The objective of this study was to evaluate the potential analgesic action of 8% capsaic in cream for topical use in patients with my ofascialpain syndrome.

Initially, cream for mulations of PLA (Placebo) and CPS (Capsaicin 8%) were developed and approved according to the current requirements of the health authority agency.

The 40 participating patients were randomly assigned to the PLA and CPS groups in a double-blind fashion.

The cream was applied to the area of the skin over the trigger point, represented by the area with pain at palpation, in an amount of 10 g for 30 minutes in a circular area of 24 mm diameter.

Subsequently, the cream was removed and the skin to lerability parameters were evaluated.

The pain was measured before and during the formulation application,aswell asat 1hour, 7days,30 days,and 60 days after the procedure, evaluated using a verbal numerical scale (from 0 to 10: with 0 = no pain and 10 = worst pain imaginable).

No patient in PLA Group hadhyperemia or burning sensation at the site of application, while 85% of patients in CPS Group had hyperemia or burning sensation at 15 minutes. These complaints disappeared 24 hours after the cream was removed. The pain score in CPS Group decreased steadily up to the 60 day of evaluation (p < 0.0001).

Capsaicin 8%, as topically applied in this clinical study inpatients with MPS, showed significant analgesic effect.

This analgesia persisted for almost two months after asingle application with out producing significant adverse effects.

Step1: Apply Lidocaine Gel 10% on the affected area for 30-40 minutes, Trigger point of pain.
Step2: Than after removing the Lidocaine Gel, apply C-Cum Gelin an amount of 10 g for 30 minutes in a circular area of 24 mm diameter.
Step3: Remove the remaining gel from a soft cotton cloth.

Burning sensation, Redness, itching, orirritationat the place where C-Cum Gel was applied. Generally these side effects occurein 6-8% occure in 6-8% of patients population, and are transient.In addition to that, it’s the characteristics of the active ingredient, that is Capsiacin.